Major resurfacing work will see the main A259 road between Rye and Hastings closed for three weeks from Monday March 9.
The closure will be in place between 8pm and 6am each night with traffic diverted off the road at Rye following a route along the A268 and A28.
Residents within the work area will be escorted to and from their properties by staff onsite.
The Highways Agency says that as well as replacing road markings and cat’s eyes, the work will prolong the life of the carriageway and reduce the need for future potential disruption to road users.
The Highways Agency is holding a public information session about the closure at Winchelsea New Hall on Monday February 23 from 3pm to 8pm.
Representatives from the Highways Agency will be available to answer questions about the scheme and its associated work.
Anita Waterton, Highways Agency Service Delivery Manager said, “We look forward to meeting residents and road users to answer any questions they may have about the work on the A259.”
A Highways Agency spokesman said: “We plan maintenance and improvement projects carefully to allow road works to be completed safely, in a cost effective way while keeping disruption to road users to a minimum.
“We do as much work as possible overnight and when roads are less busy in order to keep more lanes open for road users at peak travel times. Drivers are advised to check their route for road works and allow extra time for their journeys where needed. We will do all we can to keep road users informed.”