The A21 has been criticised by East Sussex Coroner Alan Craze.
The road has been named as one of the most dangerous in Britain due to its high percentage of fatal and serious accidents.
Mr Craze spoke at the recent inquest of Dartford Biker Alan Ellis, who died near Whatlington when his 900cc Yamaha bike rounded a corner and collided with stationary traffic,
He said: “It is like a narrow B-road with bends.
“We have a road that probably started out as a cart track and has now become a very busy main road.
“It is dangerous without any shadow of a doubt but I am not sure how we can sort this out.”
It is not the first time Mr Craze has commented on the A21.
He spoke about the dangers in 2013 at the inquest of St Leonards man Mustafa Cicek, 36, who died when his Ford Fiesta failed to negotiate a sharp bend on the road at Whatlington.
The inquest heard from Deborah and Aldo Esposito who live on the bend and for more than a decade have called for improved safety measures following a series of serious crashes.
In 1999, an Austin Metro left the road, ploughed through a fence and landed in the couple’s garden - coming to a rest near the nursery which had been decorated in preparation for their unborn child.
Mr Craze said: “Mr Craze said: “If whatever criteria this road is graded on, if someone takes the view it’s dangerous, one option would be to straighten it out with compulsory acquisition.”
He said he would write to the Secretary of State for Transport to ask him to look into what action can be taken to prevent further fatalities on that stretch of the A21.
An interactive electronic warning sign was installed at Whatlington in 2004, but the Highways Agency stopped short of installing a crash barrier claiming there was insufficient room.
Overgrown vegetation on the road also causes a hazard by obscuring the view.